scholar.google.com › citations
These proteases are prime therapeutic targets. A transmembrane aspartic protease with all the known characteristics of beta-secretase was cloned and ...
People also ask
What 2 proteins are involved in Alzheimer's disorder?
What is the secretase in Alzheimer's disease?
Which enzyme is responsible for Alzheimer's disease?
What is the amyloid precursor protein in Alzheimer's disease?
BACE1 has two aspartic protease active site motifs, DTGS (residues 93–96) and DSGT (residues 289–292), and mutation of either aspartic acid renders the enzyme ...
Nov 15, 2007 · During 1999–2000, five teams concluded that the novel transmembrane aspartic protease BACE1 (also named memapsin and Asp2) was the β-secretase [ ...
Dec 2, 1999 · Here we identify a new membrane-bound aspartyl protease (Asp2) with β-secretase activity. The Asp2 gene is expressed widely in brain and other ...
These proteases are prime therapeutic targets. A transmembrane aspartic protease with all the known characteristics of β-secretase was cloned and characterized.
People also search for
Related health topics
For informational purposes only. Consult your local medical authority for advice.
Apr 15, 2021 · BACE1 (beta-site amyloid precursor protein [APP] cleaving enzyme 1) is an aspartyl protease of the pepsin family and was discovered in 1999.
Solubilized Asp2 protein cleaves a synthetic APP peptide substrate at the beta-secretase site, and the rate of cleavage is increased tenfold by a mutation ...
The cDNAs of two new human membrane-associated aspartic proteases, memapsin 1 and memapsin 2, have been cloned and sequenced ... Alzheimer's disease. Recombinant ...
β-Secretase (memapsin 2, BACE1) is an attractive target for the development of inhibitor drugs to treat Alzheimer's disease (AD).
Beta-secretase is an aspartic-acid protease important in the pathogenesis of Alzheimer's disease, and in the formation of myelin sheaths in peripheral nerve ...